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Biostatistics 2



September 12, 2014 to October 10, 2014 February 13, 2015 to March 13, 2015 September 04, 2015 to October 02, 2015 February 12, 2016 to March 11, 2016 September 02, 2016 to September 30, 2016 February 10, 2017 to March 10, 2017 September 01, 2017 to September 29, 2017 February 09, 2018 to March 09, 2018

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Biostatistics 2

taught by Abhaya Indrayan

Aim of Course:

This course covers clinical trial designs including randomized controlled trials, ROC curves, CI and tests for relative risk and odds ratio, and an introduction to survival analysis.

This course may be taken individually (one-off) or as part of a certificate program.

Course Program:

WEEK 1: Introduction to Designs for Clinical Trials

  • Control group
  • Randomization and matching
  • Blinding and masking
  • One-way, two-way and repeated measures designs
  • Cross-over design

WEEK 2: ROC Curves

  • Review of sensitivity-specificity
  • Serial and parallel tests
  • ROC curve
  • Predictivity-based ROC curve
  • Clinical gains from a test

WEEK 3: Relative Risk (RR) and Odds Ratio (OR)

  • Definitions and applicability of RR and OR
  • CI and test of hypothesis for RR
  • CI and test of hypothesis for attributable risk
  • CI and test of hypothesis for OR

WEEK 4: Introductory Survival Analysis

  • Censored durations and need of special methods
  • Life table method
  • Kaplan-Meier method


Homework in this course consists of short answer questions to test concepts, guided data analysis problems using software and a final exam.

In addition to assigned readings, this course also has supplemental readings available online, and an exam.

Biostatistics 2


September 12, 2014 to October 10, 2014 February 13, 2015 to March 13, 2015 September 04, 2015 to October 02, 2015 February 12, 2016 to March 11, 2016 September 02, 2016 to September 30, 2016 February 10, 2017 to March 10, 2017 September 01, 2017 to September 29, 2017 February 09, 2018 to March 09, 2018

Course Fee: $629

Do you meet course prerequisites? What about book & software? (Click here to learn more)

Tuition Savings:  When you register online for 3 or more courses, $200 is automatically deducted from the total tuition. (This offer cannot be combined and is only applicable to courses of 3 weeks or longer.)

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Add $50 service fee if you require a prior invoice, or if you need to submit a purchase order or voucher, pay by wire transfer or EFT, or refund and reprocess a prior payment. Please use this printed registration form, for these and other special orders.

Courses may fill up at any time and registrations are processed in the order in which they are received. Your registration will be confirmed for the first available course date, unless you specify otherwise.

Biostatistics 2

taught by Abhaya Indrayan

Who Should Take This Course:

This non-mathematical course is specially designed for medical and health professionals who deal with medical data and want to acquire some statistical skills. These include nursing, pharmacy, laboratory technology and nutrition professionals beside physicians, surgeons and dentists.



These are listed for your benefit so you can determine for yourself, whether you have the needed background, whether from taking the listed courses, or by other experience.

If you are unclear as to whether you have mastered the above requirements, try these placement tests.

*Although we recommend taking Biostatistics 1 prior to Biostatistics 2, most of the topics in Biostatistics 2 can be undertaken on their own, if you have mastered the material in statistics 1 and 2.

Organization of the Course:

This course takes place online at the Institute for 4 weeks. During each course week, you participate at times of your own choosing - there are no set times when you must be online. Course participants will be given access to a private discussion board. In class discussions led by the instructor, you can post questions, seek clarification, and interact with your fellow students and the instructor.

At the beginning of each week, you receive the relevant material, in addition to answers to exercises from the previous session. During the week, you are expected to go over the course materials, work through exercises, and submit answers. Discussion among participants is encouraged. The instructor will provide answers and comments, and at the end of the week, you will receive individual feedback on your homework answers.

Time Requirement: about 15 hours per week, at times of  your choosing.

Students come to The Institute for a variety of reasons. As you begin the course, you will be asked to specify your category:
  1. You may be interested only in learning the material presented, and not be concerned with grades or a record of completion.
  2. You may be enrolled in PASS (Programs in Analytics and Statistical Studies) that requires demonstration of proficiency in the subject, in which case your work will be assessed for a grade.
  3. You may require a "Record of Course Completion," along with professional development credit in the form of Continuing Education Units (CEU's).  For those successfully completing the course, 5.0 CEU's and a record of course completion will be issued by The Institute, upon request.
  4. You may need academic credit:  While each institution makes its own decisions about whether to grant credit and how much to grant, most U.S. higher education institutions participate in the American Council on Education's (ACE) credit recommendation service.  ACE has evaluated and recommended college credit of 3.00 Semester Hours in Statistics, Medicine, or Biotechnology for Introduction to Biostatistics by taking both Biostatistics 1 and Biostatistics 2 in the upper division baccalaureate degree category (requires marks of 70% or better on the two courses combined, including a single proctored final online exam scheduled at the end of the second course).

Course Text:

The course text is Medical Biostatistics, third ed., by Abhaya Indrayan, which you can order from CRC Press.



Course participants should have access to a standard statistical software package for use in course exercises, including obtaining CI's, performing tests of significance including two-way ANOVA and multiple comparisons tests, survival analysis, and producing ROC curves.

Stata, SAS and R have these capabilities and are supported by Statistics.com teaching assistants. Statcrunch has these capabilities, except for survival analysis (which is needed in the last half of the fourth week), and is also supported by Statistics.com teaching assistants. JMP, SPSS and Systat also have these capabilities. More information about obtaining free or nominal cost versions of standard software packages.

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